X-ray diffraction
2.9Å resolution

Crystal structure of human katanin AAA ATPase domain complex with ATPgammaS

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Katanin p60 ATPase-containing subunit A1 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O75449 (Residues: 183-489; Coverage: 63%)
Gene name: KATNA1
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P65
Unit cell:
a: 68.907Å b: 68.907Å c: 138.698Å
α: 90° β: 90° γ: 120°
R R work R free
0.249 0.247 0.285
Expression system: Escherichia coli