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Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine

X-ray diffraction
2.3Å resolution
PDB entry 5zni coloured by chain, front view.
PDB entry 5zni coloured by chain, side view.
PDB entry 5zni coloured by chain, top view.
Source organism: Plasmodium falciparum
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo hexamer
Accessible surface area: 46216.22 Å2
Buried surface area: 21989.08 Å2
Dissociation area: 4,338.81 Å2
Dissociation energy (ΔGdiss): 35.5 kcal/mol
Dissociation entropy (TΔSdiss): 29.1 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-186155

Macromolecules

Purine nucleoside phosphorylase
Chain: A
Length: 245 amino acids
Theoretical weight: 26.89 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8T9Z7 (Residues: 1-245; Coverage: 100%)
Gene name: PNP
Pfam: Phosphorylase superfamily
InterPro:
CATH: Nucleoside phosphorylase domain
Purine nucleoside phosphorylase in PDB entry 5zni, assembly 1, front view.
Purine nucleoside phosphorylase in PDB entry 5zni, assembly 1, side view.
Purine nucleoside phosphorylase in PDB entry 5zni, assembly 1, top view.
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