PDBe 5zni

X-ray diffraction
2.3Å resolution

Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine

Released:

Function and Biology Details

Reaction catalysed:
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Purine nucleoside phosphorylase Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 26.89 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8T9Z7 (Residues: 1-245; Coverage: 100%)
Gene name: PNP
Sequence domains: Phosphorylase superfamily

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: R32
Unit cell:
a: 95.591Å b: 95.591Å c: 136.571Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.179 0.246
Expression system: Escherichia coli