› 5zjf

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reaction catalysed: 
(S)-lactate + NAD(+) = pyruvate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate dehydrogenase A chain Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 337 amino acids
Theoretical weight: 37.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00338 (Residues: 2-332; Coverage: 100%)
Gene names: LDHA, PIG19
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 9G9 1 x 9G9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P21
Unit cell:
a: 134.226Å b: 141.495Å c: 144.079Å
α: 90° β: 110.18° γ: 90°
R-values:
R R work R free
0.184 0.181 0.239
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications.
Zhong et al. (2022)
3 more

2 mentions without citation

Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid.
Chung et al. (2019)
1 more