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Crystal Structure of TtNRS

Source organism: Thermus thermophilus
Biochemical function: ATP binding
Biological process: asparaginyl-tRNA aminoacylation
Cellular component: cytoplasm

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EC 6.1.1.22: Asparagine--tRNA ligase

Reaction catalysed:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
Systematic name:
L-asparagine:tRNA(Asn) ligase (AMP-forming)
Alternative Name(s):
  • Asparagine translase
  • Asparaginyl transfer RNA synthetase
  • Asparaginyl transfer ribonucleic acid synthetase
  • Asparaginyl-tRNA synthetase
  • Asparaginyl-transfer ribonucleate synthetase
  • Asparagyl-transfer RNA synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00152
Domain description: tRNA synthetases class II (D, K and N)
Occurring in:
  1. Asparagine--tRNA ligase
The deposited structure of PDB entry 5zg8 contains 1 copy of Pfam domain PF00152 (tRNA synthetases class II (D, K and N) ) in Asparagine--tRNA ligase. Showing 1 copy in chain A.

PF01336
Domain description: OB-fold nucleic acid binding domain
Occurring in:
  1. Asparagine--tRNA ligase
The deposited structure of PDB entry 5zg8 contains 1 copy of Pfam domain PF01336 (OB-fold nucleic acid binding domain) in Asparagine--tRNA ligase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002312
Domain description: Aspartyl/Asparaginyl-tRNA synthetase, class IIb
Occurring in:
  1. Asparagine--tRNA ligase
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. Asparagine--tRNA ligase
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Asparagine--tRNA ligase
IPR004522
Domain description: Asparagine-tRNA ligase
Occurring in:
  1. Asparagine--tRNA ligase
IPR006195
Domain description: Aminoacyl-tRNA synthetase, class II
Occurring in:
  1. Asparagine--tRNA ligase
IPR004364
Domain description: Aminoacyl-tRNA synthetase, class II (D/K/N)
Occurring in:
  1. Asparagine--tRNA ligase
IPR004365
Domain description: OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Occurring in:
  1. Asparagine--tRNA ligase

Structure domains

CATH CATH domains
3.30.930.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: BirA Bifunctional Protein; domain 2
Homology: Bira Bifunctional Protein; Domain 2
Occurring in:
  1. Asparagine--tRNA ligase
The deposited structure of PDB entry 5zg8 contains 1 copy of CATH domain 3.30.930.10 (BirA Bifunctional Protein; domain 2) in Asparagine--tRNA ligase. Showing 1 copy in chain A.
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. Asparagine--tRNA ligase
The deposited structure of PDB entry 5zg8 contains 1 copy of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Asparagine--tRNA ligase. Showing 1 copy in chain A.

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