5yyf

X-ray diffraction
1.9Å resolution

Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group

Released:
Source organism: Homo sapiens
Entry authors: Li Y, Li H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein AF-9 Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 16.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42568 (Residues: 1-138; Coverage: 24%)
Gene names: AF9, MLLT3, YEATS3
Sequence domains: YEATS family
Structure domains: YEATS domain
Peptide inhibitor PHQ-H3(Q5-K9) Chains: B, D
Molecule details ›
Chains: B, D
Length: 7 amino acids
Theoretical weight: 755 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2
Unit cell:
a: 91.536Å b: 43.992Å c: 89.053Å
α: 90° β: 95.86° γ: 90°
R-values:
R R work R free
0.203 0.202 0.224
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided