5ywx

X-ray diffraction
1.74Å resolution

Crystal structure of hematopoietic prostaglandin D synthase in complex with F092

Released:
Source organism: Homo sapiens
Entry authors: Kamo M, Furubayashi N, Inaka K, Aritake K, Omura A, Tanaka A

Function and Biology Details

Reactions catalysed:
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hematopoietic prostaglandin D synthase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 198 amino acids
Theoretical weight: 23.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60760 (Residues: 2-199; Coverage: 100%)
Gene names: GSTS, HPGDS, PGDS, PTGDS2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 4 x GSH
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 47.04Å b: 48.17Å c: 92.11Å
α: 98.97° β: 92.34° γ: 90.01°
R-values:
R R work R free
0.206 0.203 0.253
Expression system: Escherichia coli