Assemblies
Assembly Name:
Isocitrate dehydrogenase [NAD] mitochondrial
Multimeric state:
hetero dimer
Accessible surface area:
25775.48 Å2
Buried surface area:
7034.33 Å2
Dissociation area:
2,540.64
Å2
Dissociation energy (ΔGdiss):
35.37
kcal/mol
Dissociation entropy (TΔSdiss):
13.75
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-156145
Macromolecules
Chain: A
Length: 339 amino acids
Theoretical weight: 36.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
Length: 339 amino acids
Theoretical weight: 36.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P50213 (Residues: 28-366; Coverage: 93%)
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
- Isocitrate dehydrogenase NAD-dependent
- Isopropylmalate dehydrogenase-like domain
- Isocitrate/isopropylmalate dehydrogenase, conserved site
![Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial in PDB entry 5yvt, assembly 1, front view.](https://www.ebi.ac.uk/pdbe/static/entry/5yvt_entity_1_front_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>5yvt</span> contains 1 copy of <span class='highlight'>Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial</span>. Front view.")
![Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial in PDB entry 5yvt, assembly 1, side view.](https://www.ebi.ac.uk/pdbe/static/entry/5yvt_entity_1_side_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>5yvt</span> contains 1 copy of <span class='highlight'>Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial</span>. Side view.")
![Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial in PDB entry 5yvt, assembly 1, top view.](https://www.ebi.ac.uk/pdbe/static/entry/5yvt_entity_1_top_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>5yvt</span> contains 1 copy of <span class='highlight'>Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial</span>. Top view.")
Chain: B
Length: 354 amino acids
Theoretical weight: 38.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
Length: 354 amino acids
Theoretical weight: 38.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P51553 (Residues: 40-393; Coverage: 90%)
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
- Isocitrate dehydrogenase NAD-dependent
- Isopropylmalate dehydrogenase-like domain
- Isocitrate/isopropylmalate dehydrogenase, conserved site
![Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial in PDB entry 5yvt, assembly 1, front view.](https://www.ebi.ac.uk/pdbe/static/entry/5yvt_entity_2_front_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>5yvt</span> contains 1 copy of <span class='highlight'>Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial</span>. Front view.")
![Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial in PDB entry 5yvt, assembly 1, side view.](https://www.ebi.ac.uk/pdbe/static/entry/5yvt_entity_2_side_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>5yvt</span> contains 1 copy of <span class='highlight'>Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial</span>. Side view.")
![Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial in PDB entry 5yvt, assembly 1, top view.](https://www.ebi.ac.uk/pdbe/static/entry/5yvt_entity_2_top_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>5yvt</span> contains 1 copy of <span class='highlight'>Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial</span>. Top view.")