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Crystal structure of Karyopherin beta2 in complex with FUS(371-526)

X-ray diffraction
3.15Å resolution
PDB entry 5yvh coloured by chain, front view.
PDB entry 5yvh coloured by chain, side view.
PDB entry 5yvh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transportin-1 and RNA-binding protein FUS
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Multimeric state: hetero dimer
Accessible surface area: 38163.45 Å2
Buried surface area: 2557.93 Å2
Dissociation area: 1,278.97 Å2
Dissociation energy (ΔGdiss): 9.69 kcal/mol
Dissociation entropy (TΔSdiss): 9.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152978

Macromolecules

Transportin-1
Chain: A
Length: 868 amino acids
Theoretical weight: 98.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92973 (Residues: 9-344, 376-898; Coverage: 96%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Pfam:
InterPro:
CATH: Leucine-rich Repeat Variant
Transportin-1 in PDB entry 5yvh, assembly 1, front view.
Transportin-1 in PDB entry 5yvh, assembly 1, side view.
Transportin-1 in PDB entry 5yvh, assembly 1, top view.
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RNA-binding protein FUS
Chain: B
Length: 158 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35637 (Residues: 371-526; Coverage: 30%)
Gene names: FUS, TLS
Pfam: Zn-finger in Ran binding protein and others
InterPro:
RNA-binding protein FUS in PDB entry 5yvh, assembly 1, front view.
RNA-binding protein FUS in PDB entry 5yvh, assembly 1, side view.
RNA-binding protein FUS in PDB entry 5yvh, assembly 1, top view.
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