5ykf

Electron Microscopy
4.33Å resolution

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-sensitive inward rectifier potassium channel 11 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 390 amino acids
Theoretical weight: 43.62 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q61743 (Residues: 1-390; Coverage: 100%)
Gene name: Kcnj11
Sequence domains:
ATP-binding cassette sub-family C member 8 isoform X2 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 1582 amino acids
Theoretical weight: 177.3 KDa
Source organism: Mesocricetus auratus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1U7R319 (Residues: 1-1582; Coverage: 100%)
Gene name: Abcc8
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.33Å
Relevant EMDB volumes: EMD-6832
Expression system: Homo sapiens