› 5yjg

X-ray diffraction
2.4Å resolution

Structural insights into periostin functions

Released:
DOI: 10.2210/pdb5yjg/pdb
PDB entry 5yjg coloured by chain, front view.
PDB entry 5yjg coloured by chain, side view.
PDB entry 5yjg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterizations of human periostin dimerization and cysteinylation.
Liu J, Zhang J, Xu F, Lin Z, Li Z, Liu H
FEBS Lett 592 1789-1803 (2018)
PMID: 29754429

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172184 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Periostin Chain: A
Molecule details ›
Chain: A
Length: 628 amino acids
Theoretical weight: 69.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15063 (Residues: 22-631; Coverage: 75%)
Gene names: OSF2, POSTN
Sequence domains: Fasciclin domain

Ligands and Environments

6 bound ligands:
Ligand NA 1 x NA
Ligand CYS 1 x CYS
Ligand CL 16 x CL
Ligand CA 6 x CA
Ligand MG 8 x MG
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P6122
Unit cell:
a: 105.605Å b: 105.605Å c: 331.225Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.212 0.248
Expression system: Homo sapiens

Quick links

Citations

2 review citations

The role of periostin in kidney diseases.
Turczyn et al. (2021)
1 more

2 mentions without citation

Development of an engineered peptide antagonist against periostin to overcome doxorubicin resistance in breast cancer.
Oo et al. (2021)
1 more