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The structure of the KANK2 ankyrin domain with the KIF21A peptide

X-ray diffraction
2.12Å resolution
PDB entry 5ybv coloured by chain, front view.
PDB entry 5ybv coloured by chain, side view.
PDB entry 5ybv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Kinesin-like protein KIF21A and KN motif and ankyrin repeat domain-containing protein 2
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Multimeric state: hetero tetramer
Accessible surface area: 22673.31 Å2
Buried surface area: 5463.94 Å2
Dissociation area: 2,229.82 Å2
Dissociation energy (ΔGdiss): 4.46 kcal/mol
Dissociation entropy (TΔSdiss): 30.07 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-179107

Macromolecules

KN motif and ankyrin repeat domain-containing protein 2
Chain: A
Length: 258 amino acids
Theoretical weight: 28.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Thermus thermophilus shuttle vector pTRH1T
UniProt:
  • Canonical: Q63ZY3 (Residues: 578-832; Coverage: 30%)
Gene names: ANKRD25, KANK2, KIAA1518, MXRA3, SIP
Pfam: Ankyrin repeats (3 copies)
InterPro:
CATH: Ankyrin repeat-containing domain
KN motif and ankyrin repeat domain-containing protein 2 in PDB entry 5ybv, assembly 1, front view.
KN motif and ankyrin repeat domain-containing protein 2 in PDB entry 5ybv, assembly 1, side view.
KN motif and ankyrin repeat domain-containing protein 2 in PDB entry 5ybv, assembly 1, top view.
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KN motif and ankyrin repeat domain-containing protein 2
Chain: B
Length: 261 amino acids
Theoretical weight: 28.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Thermus thermophilus shuttle vector pTRH1T
UniProt:
  • Canonical: Q63ZY3 (Residues: 578-832; Coverage: 30%)
Gene names: ANKRD25, KANK2, KIAA1518, MXRA3, SIP
Pfam: Ankyrin repeats (3 copies)
InterPro:
CATH: Ankyrin repeat-containing domain
KN motif and ankyrin repeat domain-containing protein 2 in PDB entry 5ybv, assembly 1, front view.
KN motif and ankyrin repeat domain-containing protein 2 in PDB entry 5ybv, assembly 1, side view.
KN motif and ankyrin repeat domain-containing protein 2 in PDB entry 5ybv, assembly 1, top view.
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Kinesin-like protein KIF21A
Chains: C, D
Length: 22 amino acids
Theoretical weight: 2.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q7Z4S6 (Residues: 1146-1167; Coverage: 1%)
Gene names: KIAA1708, KIF2, KIF21A
Kinesin-like protein KIF21A in PDB entry 5ybv, assembly 1, front view.
Kinesin-like protein KIF21A in PDB entry 5ybv, assembly 1, side view.
Kinesin-like protein KIF21A in PDB entry 5ybv, assembly 1, top view.
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