› 5yb1

X-ray diffraction
2.62Å resolution

Structure and function of human serum albumin-metal agent complex

Released:
DOI: 10.2210/pdb5yb1/pdb
PDB entry 5yb1 coloured by chain, front view.
PDB entry 5yb1 coloured by chain, side view.
PDB entry 5yb1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin.
Wang J, Gou Y, Zhang Z, Yu P, Qi J, Qin Q, Sun H, Wu X, Liang H, Yang F
Mol Pharm 15 2180-2193 (2018)
PMID: 29722993

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 581 amino acids
Theoretical weight: 66.21 KDa
Source organism: Homo sapiens
Expression system: Pichia kudriavzevii
UniProt:
  • Canonical: P02768 (Residues: 27-607; Coverage: 98%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand PLM 14 x PLM
Ligand 8ZR 2 x 8ZR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P1
Unit cell:
a: 38.492Å b: 95.653Å c: 96.642Å
α: 104.67° β: 101.43° γ: 89.97°
R-values:
R R work R free
0.222 0.219 0.278
Expression system: Pichia kudriavzevii

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Citations

1 review citation

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents.
Bai et al. (2022)
7 other articles