X-ray diffraction
1.8Å resolution

VIM-2 metallo-beta-lactamase in complex with (R)-2-(4-hydroxyphenyl)-2-((S)-3-mercapto-2-methylpropanamido)acetic acid (compound 12)

Source organism: Pseudomonas aeruginosa
Entry author: Li G-B

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Lactamase_B domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 231 amino acids
Theoretical weight: 24.68 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9K2N0 (Residues: 32-262; Coverage: 94%)
Gene names: VIM-2, bla vim-2, bla-VIM-2, blaVIM-2, blaVIM2, blasVIM-2, vim-2
Sequence domains: Metallo-beta-lactamase superfamily
Structure domains: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 101.355Å b: 74.452Å c: 64.456Å
α: 90° β: 129.46° γ: 90°
R R work R free
0.138 0.136 0.173
Expression system: Escherichia coli BL21(DE3)