5y1z

X-ray diffraction
2.68Å resolution

Crystal structure of ZMYND8 PHD-BROMO-PWWP tandem in complex with Drebrin ADF-H domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Drebrin Chains: A, B
Molecule details ›
Chains: A, B
Length: 137 amino acids
Theoretical weight: 14.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16643 (Residues: 1-135; Coverage: 21%)
Gene names: D0S117E, DBN1
Sequence domains: Cofilin/tropomyosin-type actin-binding protein
Protein kinase C-binding protein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 324 amino acids
Theoretical weight: 37.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULU4 (Residues: 83-406; Coverage: 27%)
Gene names: KIAA1125, PRKCBP1, RACK7, ZMYND8
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 54.183Å b: 138.095Å c: 161.164Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.178 0.234
Expression system: Escherichia coli