PDBe 5xxi

X-ray diffraction
2.3Å resolution

Crystal structure of CYP2C9 in complex with multiple losartan molecules

Released:
Source organism: Homo sapiens

Function and Biology Details

Reactions catalysed:
(+)-(R)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (+)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)-perillyl alcohol + [oxidized NADPH--hemoprotein reductase] + H(2)O
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2C9 Chain: A
Molecule details ›
Chain: A
Length: 463 amino acids
Theoretical weight: 52.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11712 (Residues: 28-489; Coverage: 94%)
Gene names: CYP2C10, CYP2C9
Sequence domains: Cytochrome P450

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: I222
Unit cell:
a: 74.571Å b: 142.958Å c: 161.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.204 0.269
Expression system: Escherichia coli