5xw6

X-ray diffraction
3.1Å resolution

Crystal structure of the chicken ATP-gated P2X7 receptor channel in the presence of competitive antagonist TNP-ATP at 3.1 Angstroms

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoceptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 327 amino acids
Theoretical weight: 37.34 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: E1C6P3 (Residues: 42-360; Coverage: 56%)
Gene name: P2RX7
Sequence domains: ATP P2X receptor
Structure domains: atp-gated p2x4 ion channel domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 113.038Å b: 113.038Å c: 333.472Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.248
Expression system: Homo sapiens