› 5xw6

X-ray diffraction
3.1Å resolution

Crystal structure of the chicken ATP-gated P2X7 receptor channel in the presence of competitive antagonist TNP-ATP at 3.1 Angstroms

Released:
DOI: 10.2210/pdb5xw6/pdb
PDB 5xw6 coloured by chain and viewed from the front.
PDB 5xw6 coloured by chain and viewed from the side.
PDB 5xw6 coloured by chain and viewed from the top.
Source organism: Gallus gallus
Primary publication:
Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel.
Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, Nureki O
OpenAccess logo Nat Commun 8 876 (2017)
PMID: 29026074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoceptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 327 amino acids
Theoretical weight: 37.34 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: E1C6P3 (Residues: 42-360; Coverage: 56%)
Gene name: P2RX7
Sequence domains: ATP P2X receptor
Structure domains: atp-gated p2x4 ion channel domain

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand 128 3 x 128
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 113.038Å b: 113.038Å c: 333.472Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.248
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Structural basis for the functional properties of the P2X7 receptor for extracellular ATP.
Jiang et al. (2021)
5 more