PDBe 5xti

Electron Microscopy
17.4Å resolution

Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2

Released:
Source organisms:
Primary publication:
Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
Cell 170 1247-1257.e12 (2017)
PMID: 28844695
Related structures: EMD-6776

Function and Biology Details

Reactions catalysed:
NADH + acceptor = NAD(+) + reduced acceptor
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out)
4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 138-mer (preferred)
Entry contents:
68 distinct polypeptide molecules
Macromolecules (68 distinct):
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chains: A, BA
Molecule details ›
Chains: A, BA
Length: 431 amino acids
Theoretical weight: 47.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49821 (Residues: 27-457; Coverage: 93%)
Gene names: NDUFV1, UQOR1
Sequence domains:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Chains: B, BB
Molecule details ›
Chains: B, BB
Length: 176 amino acids
Theoretical weight: 20.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O00217 (Residues: 35-210; Coverage: 84%)
Gene name: NDUFS8
Sequence domains: 4Fe-4S dicluster domain
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Chains: BC, C
Molecule details ›
Chains: BC, C
Length: 156 amino acids
Theoretical weight: 17.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75251 (Residues: 58-213; Coverage: 73%)
Gene name: NDUFS7
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Chains: BE, E
Molecule details ›
Chains: BE, E
Length: 113 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56556 (Residues: 16-128; Coverage: 88%)
Gene names: LYRM6, NADHB14, NDUFA6
Sequence domains: Complex 1 protein (LYR family)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Chains: BF, F
Molecule details ›
Chains: BF, F
Length: 83 amino acids
Theoretical weight: 9.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43678 (Residues: 14-96; Coverage: 84%)
Gene name: NDUFA2
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Acyl carrier protein, mitochondrial Chains: BG, BX, G, X
Molecule details ›
Chains: BG, BX, G, X
Length: 85 amino acids
Theoretical weight: 9.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14561 (Residues: 72-156; Coverage: 55%)
Gene name: NDUFAB1
Sequence domains: Phosphopantetheine attachment site
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Chains: BH, H
Molecule details ›
Chains: BH, H
Length: 112 amino acids
Theoretical weight: 13.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16718 (Residues: 5-116; Coverage: 97%)
Gene name: NDUFA5
Sequence domains: ETC complex I subunit conserved region
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Chains: BI, I
Molecule details ›
Chains: BI, I
Length: 110 amino acids
Theoretical weight: 12.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95182 (Residues: 4-113; Coverage: 97%)
Gene name: NDUFA7
Sequence domains: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chains: BJ, J
Molecule details ›
Chains: BJ, J
Length: 337 amino acids
Theoretical weight: 38.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16795 (Residues: 40-376; Coverage: 89%)
Gene names: NDUFA9, NDUFS2L
Sequence domains: NAD dependent epimerase/dehydratase family
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Chains: BK, K
Molecule details ›
Chains: BK, K
Length: 33 amino acids
Theoretical weight: 3.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56181 (Residues: 74-106; Coverage: 31%)
Gene name: NDUFV3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chains: BL, L
Molecule details ›
Chains: BL, L
Length: 118 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43181 (Residues: 58-175; Coverage: 67%)
Gene name: NDUFS4
Sequence domains: ETC complex I subunit conserved region
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chains: BM, M
Molecule details ›
Chains: BM, M
Length: 687 amino acids
Theoretical weight: 75.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28331 (Residues: 30-716; Coverage: 95%)
Gene name: NDUFS1
Sequence domains:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Chains: BN, N
Molecule details ›
Chains: BN, N
Length: 143 amino acids
Theoretical weight: 16.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UI09 (Residues: 2-144; Coverage: 99%)
Gene names: DAP13, NDUFA12
Sequence domains: NADH ubiquinone oxidoreductase subunit NDUFA12
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Chains: BO, O
Molecule details ›
Chains: BO, O
Length: 212 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P19404 (Residues: 36-247; Coverage: 85%)
Gene name: NDUFV2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Chains: BP, P
Molecule details ›
Chains: BP, P
Length: 208 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75489 (Residues: 43-250; Coverage: 79%)
Gene name: NDUFS3
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Chains: BQ, Q
Molecule details ›
Chains: BQ, Q
Length: 430 amino acids
Theoretical weight: 49.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75306 (Residues: 34-463; Coverage: 93%)
Gene name: NDUFS2
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chains: BS, S
Molecule details ›
Chains: BS, S
Length: 70 amino acids
Theoretical weight: 8.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15239 (Residues: 1-70; Coverage: 100%)
Gene name: NDUFA1
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chains: BT, T
Molecule details ›
Chains: BT, T
Length: 95 amino acids
Theoretical weight: 10.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75380 (Residues: 29-123; Coverage: 77%)
Gene name: NDUFS6
Sequence domains: Zinc-finger domain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chains: BU, U
Molecule details ›
Chains: BU, U
Length: 83 amino acids
Theoretical weight: 9.16 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95167 (Residues: 2-84; Coverage: 99%)
Gene name: NDUFA3
Sequence domains: NADH dehydrogenase 1 alpha subcomplex subunit 3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chains: BV, V
Molecule details ›
Chains: BV, V
Length: 140 amino acids
Theoretical weight: 14.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q86Y39 (Residues: 2-141; Coverage: 99%)
Gene name: NDUFA11
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chains: BW, W
Molecule details ›
Chains: BW, W
Length: 138 amino acids
Theoretical weight: 16.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0J0 (Residues: 7-144; Coverage: 96%)
Gene names: CDA016, CGI-39, GRIM19, NDUFA13
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Chains: BY, Y
Molecule details ›
Chains: BY, Y
Length: 59 amino acids
Theoretical weight: 7.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95178 (Residues: 39-97; Coverage: 56%)
Gene name: NDUFB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Chains: BZ, Z
Molecule details ›
Chains: BZ, Z
Length: 80 amino acids
Theoretical weight: 9.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43676 (Residues: 10-89; Coverage: 82%)
Gene name: NDUFB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chains: Ba, a
Molecule details ›
Chains: Ba, a
Length: 138 amino acids
Theoretical weight: 16.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43674 (Residues: 52-189; Coverage: 73%)
Gene name: NDUFB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Chains: Bb, b
Molecule details ›
Chains: Bb, b
Length: 124 amino acids
Theoretical weight: 15.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95139 (Residues: 3-126; Coverage: 97%)
Gene name: NDUFB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Chains: Bc, c
Molecule details ›
Chains: Bc, c
Length: 153 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95169 (Residues: 34-186; Coverage: 82%)
Gene name: NDUFB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chains: Bd, d
Molecule details ›
Chains: Bd, d
Length: 171 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O96000 (Residues: 1-171; Coverage: 99%)
Gene name: NDUFB10
Sequence domains: NADH-ubiquinone oxidoreductase subunit 10
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Chains: Be, e
Molecule details ›
Chains: Be, e
Length: 97 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NX14 (Residues: 54-150; Coverage: 63%)
Gene names: NDUFB11, UNQ111/PRO1064
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Chains: Bf, f
Molecule details ›
Chains: Bf, f
Length: 47 amino acids
Theoretical weight: 5.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43677 (Residues: 28-74; Coverage: 62%)
Gene name: NDUFC1
NADH dehydrogenase [ubiquinone] 1 subunit C2 Chains: Bg, g
Molecule details ›
Chains: Bg, g
Length: 119 amino acids
Theoretical weight: 14.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95298 (Residues: 1-119; Coverage: 100%)
Gene names: HLC1, NDUFC2
Sequence domains: NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Chains: Bh, h
Molecule details ›
Chains: Bh, h
Length: 104 amino acids
Theoretical weight: 12.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43920 (Residues: 2-105; Coverage: 98%)
Gene name: NDUFS5
NADH-ubiquinone oxidoreductase chain 2 Chains: Bi, i
Molecule details ›
Chains: Bi, i
Length: 347 amino acids
Theoretical weight: 39.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q4GRX1 (Residues: 1-347; Coverage: 100%)
Gene names: NADH2, ND2
Sequence domains:
NADH-ubiquinone oxidoreductase chain 3 Chains: Bj, j
Molecule details ›
Chains: Bj, j
Length: 115 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: B9EE38 (Residues: 1-115; Coverage: 99%)
Gene name: NADH3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
NADH-ubiquinone oxidoreductase chain 4L Chains: Bk, k
Molecule details ›
Chains: Bk, k
Length: 97 amino acids
Theoretical weight: 10.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: V9JN72 (Residues: 1-97; Coverage: 99%)
Gene name: ND4L
NADH-ubiquinone oxidoreductase chain 5 Chains: Bl, l
Molecule details ›
Chains: Bl, l
Length: 603 amino acids
Theoretical weight: 67.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: X5BVZ3 (Residues: 1-603; Coverage: 100%)
Gene name: ND5
Sequence domains:
NADH-ubiquinone oxidoreductase chain 6 Chains: Bm, m
Molecule details ›
Chains: Bm, m
Length: 174 amino acids
Theoretical weight: 18.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8HAX7 (Residues: 1-174; Coverage: 100%)
Gene name: ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Chains: Bn, n
Molecule details ›
Chains: Bn, n
Length: 56 amino acids
Theoretical weight: 6.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75438 (Residues: 3-58; Coverage: 97%)
Gene name: NDUFB1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Chains: Bo, o
Molecule details ›
Chains: Bo, o
Length: 128 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95168 (Residues: 2-129; Coverage: 99%)
Gene name: NDUFB4
Sequence domains: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chains: Bp, p
Molecule details ›
Chains: Bp, p
Length: 172 amino acids
Theoretical weight: 21.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y6M9 (Residues: 8-179; Coverage: 96%)
Gene names: LYRM3, NDUFB9, UQOR22
Sequence domains: Complex 1 protein (LYR family)
NADH-ubiquinone oxidoreductase chain 4 Chains: Br, r
Molecule details ›
Chains: Br, r
Length: 459 amino acids
Theoretical weight: 51.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: B2XJG5 (Residues: 1-459; Coverage: 100%)
Gene name: ND4
Sequence domains:
NADH-ubiquinone oxidoreductase chain 1 Chains: Bs, s
Molecule details ›
Chains: Bs, s
Length: 318 amino acids
Theoretical weight: 35.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: H9PGF0 (Residues: 1-318; Coverage: 100%)
Gene name: ND1
Sequence domains: NADH dehydrogenase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chains: Bu, u
Molecule details ›
Chains: Bu, u
Length: 169 amino acids
Theoretical weight: 19.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P51970 (Residues: 4-172; Coverage: 98%)
Gene name: NDUFA8
Sequence domains: CHCH domain
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chains: Bv, v
Molecule details ›
Chains: Bv, v
Length: 122 amino acids
Theoretical weight: 15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P17568 (Residues: 3-124; Coverage: 89%)
Gene name: NDUFB7
Sequence domains: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Chains: Bw, w
Molecule details ›
Chains: Bw, w
Length: 320 amino acids
Theoretical weight: 37.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95299 (Residues: 36-355; Coverage: 90%)
Gene name: NDUFA10
Sequence domains: Deoxynucleoside kinase
Cytochrome c oxidase subunit 1 Chains: Bx, x
Molecule details ›
Chains: Bx, x
Length: 514 amino acids
Theoretical weight: 57.07 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00396 (Residues: 1-514; Coverage: 100%)
Gene names: COI, COXI, MT-CO1, MTCO1
Sequence domains: Cytochrome C and Quinol oxidase polypeptide I
Cytochrome c oxidase subunit 2 Chains: By, y
Molecule details ›
Chains: By, y
Length: 227 amino acids
Theoretical weight: 26.04 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P68530 (Residues: 1-227; Coverage: 100%)
Gene names: COII, COX2, COXII, MT-CO2, MTCO2
Sequence domains:
Cytochrome c oxidase subunit 3 Chains: Bz, z
Molecule details ›
Chains: Bz, z
Length: 261 amino acids
Theoretical weight: 29.96 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00415 (Residues: 1-261; Coverage: 100%)
Gene names: COIII, COXIII, MT-CO3, MTCO3
Sequence domains: Cytochrome c oxidase subunit III
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Chains: 0, B0
Molecule details ›
Chains: 0, B0
Length: 144 amino acids
Theoretical weight: 16.91 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00423 (Residues: 26-169; Coverage: 85%)
Gene names: COX4, COX4I1
Sequence domains: Cytochrome c oxidase subunit IV
Cytochrome c oxidase subunit 5A, mitochondrial Chains: 1, B1
Molecule details ›
Chains: 1, B1
Length: 109 amino acids
Theoretical weight: 12.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00426 (Residues: 44-152; Coverage: 72%)
Gene name: COX5A
Sequence domains: Cytochrome c oxidase subunit Va
Cytochrome c oxidase subunit 5B, mitochondrial Chains: 2, B2
Molecule details ›
Chains: 2, B2
Length: 98 amino acids
Theoretical weight: 10.68 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00428 (Residues: 32-129; Coverage: 76%)
Gene name: COX5B
Cytochrome c oxidase subunit 6A2, mitochondrial Chains: 3, B3
Molecule details ›
Chains: 3, B3
Length: 84 amino acids
Theoretical weight: 9.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07471 (Residues: 13-96; Coverage: 87%)
Gene names: COX6A, COX6A2
Cytochrome c oxidase subunit 6B1 Chains: 4, B4
Molecule details ›
Chains: 4, B4
Length: 75 amino acids
Theoretical weight: 8.93 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00429 (Residues: 12-86; Coverage: 87%)
Gene names: COX6B, COX6B1
Sequence domains: Cytochrome oxidase c subunit VIb
Cytochrome c oxidase subunit 6C Chains: 5, B5
Molecule details ›
Chains: 5, B5
Length: 73 amino acids
Theoretical weight: 8.49 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04038 (Residues: 2-74; Coverage: 99%)
Gene name: COX6C
Sequence domains: Cytochrome c oxidase subunit VIc
Cytochrome c oxidase subunit 7A1, mitochondrial Chains: 6, B6
Molecule details ›
Chains: 6, B6
Length: 56 amino acids
Theoretical weight: 6.29 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07470 (Residues: 22-77; Coverage: 70%)
Gene names: COX7A, COX7A1, COX7AH
Sequence domains: Cytochrome c oxidase subunit VII
Cytochrome c oxidase subunit 7B, mitochondrial Chains: 7, B7
Molecule details ›
Chains: 7, B7
Length: 49 amino acids
Theoretical weight: 5.44 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13183 (Residues: 30-78; Coverage: 61%)
Gene name: COX7B
Cytochrome c oxidase subunit 7C, mitochondrial Chains: 8, B8
Molecule details ›
Chains: 8, B8
Length: 47 amino acids
Theoretical weight: 5.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00430 (Residues: 17-63; Coverage: 75%)
Gene names: COX7C, COX7CP1
Cytochrome c oxidase subunit 8B, mitochondrial Chains: 9, B9
Molecule details ›
Chains: 9, B9
Length: 43 amino acids
Theoretical weight: 4.74 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P10175 (Residues: 25-67; Coverage: 61%)
Gene names: COX8B, COX8H
Sequence domains: Cytochrome oxidase c subunit VIII
Cytochrome b-c1 complex subunit 8 Chains: AA, AN
Molecule details ›
Chains: AA, AN
Length: 81 amino acids
Theoretical weight: 9.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14949 (Residues: 2-82; Coverage: 99%)
Gene name: UQCRQ
Sequence domains: UcrQ family
Cytochrome b-c1 complex subunit 9 Chains: AB, AO
Molecule details ›
Chains: AB, AO
Length: 57 amino acids
Theoretical weight: 5.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P47985 (Residues: 1-57; Coverage: 21%)
Gene name: UQCRFS1
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chains: AC, AP
Molecule details ›
Chains: AC, AP
Length: 196 amino acids
Theoretical weight: 21.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P47985 (Residues: 79-274; Coverage: 72%)
Gene name: UQCRFS1
Sequence domains:
Cytochrome b-c1 complex subunit 9 Chains: AD, AQ
Molecule details ›
Chains: AD, AQ
Length: 62 amino acids
Theoretical weight: 7.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UDW1 (Residues: 2-63; Coverage: 98%)
Gene names: HSPC119, UCRC, UQCR10
Sequence domains: Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Cytochrome b-c1 complex subunit 6, mitochondrial Chains: AE, AR
Molecule details ›
Chains: AE, AR
Length: 74 amino acids
Theoretical weight: 8.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07919 (Residues: 18-91; Coverage: 81%)
Gene name: UQCRH
Sequence domains: Ubiquinol-cytochrome C reductase hinge protein
Cytochrome b-c1 complex subunit 7 Chains: AF, AS
Molecule details ›
Chains: AF, AS
Length: 106 amino acids
Theoretical weight: 13.04 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P14927 (Residues: 6-111; Coverage: 96%)
Gene names: UQBP, UQCRB
Sequence domains: Ubiquinol-cytochrome C reductase complex 14kD subunit
Cytochrome b-c1 complex subunit 10 Chains: AG, AT
Molecule details ›
Chains: AG, AT
Length: 51 amino acids
Theoretical weight: 5.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14957 (Residues: 2-52; Coverage: 91%)
Gene names: UQCR, UQCR11
Cytochrome c1, heme protein, mitochondrial Chains: AH, AU
Molecule details ›
Chains: AH, AU
Length: 241 amino acids
Theoretical weight: 27.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08574 (Residues: 85-325; Coverage: 74%)
Gene name: CYC1
Sequence domains: Cytochrome C1 family
Cytochrome b Chains: AJ, AV
Molecule details ›
Chains: AJ, AV
Length: 378 amino acids
Theoretical weight: 42.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00156 (Residues: 2-379; Coverage: 100%)
Gene names: COB, CYTB, MT-CYB, MTCYB
Sequence domains:
Cytochrome b-c1 complex subunit 2, mitochondrial Chains: AK, AW
Molecule details ›
Chains: AK, AW
Length: 419 amino acids
Theoretical weight: 44.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P22695 (Residues: 35-453; Coverage: 93%)
Gene name: UQCRC2
Sequence domains:
Cytochrome b-c1 complex subunit 1, mitochondrial Chains: AL, AY
Molecule details ›
Chains: AL, AY
Length: 446 amino acids
Theoretical weight: 49.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P31930 (Residues: 35-480; Coverage: 93%)
Gene name: UQCRC1
Sequence domains:

Ligands and Environments


Cofactor: Ligand FMN 2 x FMN

Cofactor: Ligand HEA 4 x HEA

Cofactor: Ligand HEC 2 x HEC

Cofactor: Ligand HEM 4 x HEM

Cofactor: Ligand NDP 2 x NDP

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 17.4Å
Relevant EMDB volumes: EMD-6776