5xl7

X-ray diffraction
2.1Å resolution

The structure of hemagglutinin Q226L mutant from an avian-origin H4N6 influenza virus in complex with human receptor analog LSTc

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin HA1 chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 35.95 KDa
Source organism: Influenza A virus (A/duck/Czechoslovakia/1956(H4N6))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19696 (Residues: 17-343; Coverage: 60%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA2 chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 176 amino acids
Theoretical weight: 20.34 KDa
Source organism: Influenza A virus (A/duck/Czechoslovakia/1956(H4N6))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19696 (Residues: 344-519; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, SIA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: R32
Unit cell:
a: 100.935Å b: 100.935Å c: 688.146Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.24
Expression system: Trichoplusia ni