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The structure of hemagglutinin from an avian-origin H4N6 influenza virus in complex with human receptor analog Lstc

X-ray diffraction
2.102Å resolution
PDB entry 5xl4 coloured by chain, front view.
PDB entry 5xl4 coloured by chain, side view.
PDB entry 5xl4 coloured by chain, top view.
Source organism: Influenza A virus (A/duck/Czechoslovakia/1956(H4N6))
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin HA2 chain
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Multimeric state: hetero dimer
Accessible surface area: 23835.18 Å2
Buried surface area: 6573.24 Å2
Dissociation area: 2,832.86 Å2
Dissociation energy (ΔGdiss): 37.15 kcal/mol
Dissociation entropy (TΔSdiss): 13.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148690
Assembly 2
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Assembly Name: Hemagglutinin HA2 chain
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Multimeric state: hetero dimer
Accessible surface area: 23819.96 Å2
Buried surface area: 6623.35 Å2
Dissociation area: 2,856.59 Å2
Dissociation energy (ΔGdiss): 36.84 kcal/mol
Dissociation entropy (TΔSdiss): 13.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148690

Macromolecules

Hemagglutinin HA1 chain
Chains: A, B
Length: 327 amino acids
Theoretical weight: 35.97 KDa
Source organism: Influenza A virus (A/duck/Czechoslovakia/1956(H4N6))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19696 (Residues: 17-343; Coverage: 60%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA1 chain in PDB entry 5xl4, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 5xl4, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 5xl4, assembly 1, top view.
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Hemagglutinin HA2 chain
Chains: C, D
Length: 176 amino acids
Theoretical weight: 20.34 KDa
Source organism: Influenza A virus (A/duck/Czechoslovakia/1956(H4N6))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19696 (Residues: 344-519; Coverage: 32%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
Hemagglutinin HA2 chain in PDB entry 5xl4, assembly 1, front view.
Hemagglutinin HA2 chain in PDB entry 5xl4, assembly 1, side view.
Hemagglutinin HA2 chain in PDB entry 5xl4, assembly 1, top view.
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