Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1/D2/F/E/G from Human
Source organism:
Homo sapiens
Biochemical function:
protein binding
Biological process: RNA splicing
Cellular component: SMN-Sm protein complex
Biological process: RNA splicing
Cellular component: SMN-Sm protein complex
Protein families (Pfam)![The deposited structure of PDB entry 5xjl contains 1 copy of Pfam domain PF01423 (LSM domain ) in Small nuclear ribonucleoprotein Sm D1. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_2_A_Pfam_PF01423_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of Pfam domain <span class='highlight'>PF01423 (LSM domain )</span> in <span class='highlight'>Small nuclear ribonucleoprotein Sm D1</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of Pfam domain PF01423 (LSM domain ) in Small nuclear ribonucleoprotein Sm D2. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_3_B_Pfam_PF01423_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of Pfam domain <span class='highlight'>PF01423 (LSM domain )</span> in <span class='highlight'>Small nuclear ribonucleoprotein Sm D2</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of Pfam domain PF01423 (LSM domain ) in Small nuclear ribonucleoprotein E. Showing 1 copy in chain D [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_4_E_Pfam_PF01423_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of Pfam domain <span class='highlight'>PF01423 (LSM domain )</span> in <span class='highlight'>Small nuclear ribonucleoprotein E</span>. Showing 1 copy in chain <span class='highlight'>D [auth E]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of Pfam domain PF01423 (LSM domain ) in Small nuclear ribonucleoprotein F. Showing 1 copy in chain E [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_5_F_Pfam_PF01423_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of Pfam domain <span class='highlight'>PF01423 (LSM domain )</span> in <span class='highlight'>Small nuclear ribonucleoprotein F</span>. Showing 1 copy in chain <span class='highlight'>E [auth F]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of Pfam domain PF01423 (LSM domain ) in Small nuclear ribonucleoprotein G. Showing 1 copy in chain F [auth G].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_6_G_Pfam_PF01423_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of Pfam domain <span class='highlight'>PF01423 (LSM domain )</span> in <span class='highlight'>Small nuclear ribonucleoprotein G</span>. Showing 1 copy in chain <span class='highlight'>F [auth G]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of Pfam domain PF20636 (Survival Motor Neuron, Gemin2-binding domain) in Survival motor neuron protein. Showing 1 copy in chain G [auth M].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_7_M_Pfam_PF20636_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of Pfam domain <span class='highlight'>PF20636 (Survival Motor Neuron, Gemin2-binding domain)</span> in <span class='highlight'>Survival motor neuron protein</span>. Showing 1 copy in chain <span class='highlight'>G [auth M]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of Pfam domain PF04938 (Survival motor neuron (SMN) interacting protein 1 (SIP1)) in Gem-associated protein 2. Showing 1 copy in chain A [auth 2].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_1_2_Pfam_PF04938_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of Pfam domain <span class='highlight'>PF04938 (Survival motor neuron (SMN) interacting protein 1 (SIP1))</span> in <span class='highlight'>Gem-associated protein 2</span>. Showing 1 copy in chain <span class='highlight'>A [auth 2]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 5xjl contains 1 copy of CATH domain 2.30.30.100 (SH3 type barrels.) in Small nuclear ribonucleoprotein Sm D1. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_2_A_CATH_2.30.30.100_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of CATH domain <span class='highlight'>2.30.30.100 (SH3 type barrels.)</span> in <span class='highlight'>Small nuclear ribonucleoprotein Sm D1</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of CATH domain 2.30.30.100 (SH3 type barrels.) in Small nuclear ribonucleoprotein Sm D2. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_3_B_CATH_2.30.30.100_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of CATH domain <span class='highlight'>2.30.30.100 (SH3 type barrels.)</span> in <span class='highlight'>Small nuclear ribonucleoprotein Sm D2</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of CATH domain 2.30.30.100 (SH3 type barrels.) in Small nuclear ribonucleoprotein E. Showing 1 copy in chain D [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_4_E_CATH_2.30.30.100_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of CATH domain <span class='highlight'>2.30.30.100 (SH3 type barrels.)</span> in <span class='highlight'>Small nuclear ribonucleoprotein E</span>. Showing 1 copy in chain <span class='highlight'>D [auth E]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of CATH domain 2.30.30.100 (SH3 type barrels.) in Small nuclear ribonucleoprotein F. Showing 1 copy in chain E [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_5_F_CATH_2.30.30.100_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of CATH domain <span class='highlight'>2.30.30.100 (SH3 type barrels.)</span> in <span class='highlight'>Small nuclear ribonucleoprotein F</span>. Showing 1 copy in chain <span class='highlight'>E [auth F]</span>.")
![The deposited structure of PDB entry 5xjl contains 1 copy of CATH domain 2.30.30.100 (SH3 type barrels.) in Small nuclear ribonucleoprotein G. Showing 1 copy in chain F [auth G].](https://www.ebi.ac.uk/pdbe/static/entry/5xjl_6_G_CATH_2.30.30.100_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5xjl</span> contains 1 copy of CATH domain <span class='highlight'>2.30.30.100 (SH3 type barrels.)</span> in <span class='highlight'>Small nuclear ribonucleoprotein G</span>. Showing 1 copy in chain <span class='highlight'>F [auth G]</span>.")