X-ray diffraction
3Å resolution

Crystal structure of uPA in complex with quercetin

Source organism: Homo sapiens
Primary publication:
A structural mechanism of flavonoids in inhibiting serine proteases.
Food Funct 8 2437-2443 (2017)
PMID: 28644504

Function and Biology Details

Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Urokinase-type plasminogen activator chain B Chain: U
Molecule details ›
Chain: U
Length: 246 amino acids
Theoretical weight: 27.72 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P00749 (Residues: 179-424; Coverage: 60%)
Gene name: PLAU
Sequence domains: Trypsin

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL19U1
Spacegroup: R3
Unit cell:
a: 119.969Å b: 119.969Å c: 41.78Å
α: 90° β: 90° γ: 120°
R R work R free
0.175 0.17 0.258
Expression system: Komagataella pastoris