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Crystal structure of Mycobacterium tuberculosis methionyl-tRNA synthetase bound by methionyl-adenylate (Met-AMP)

Source organism: Mycobacterium tuberculosis H37Ra
Biochemical function: metal ion binding
Biological process: methionyl-tRNA aminoacylation
Cellular component: cytoplasm

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EC 6.1.1.10: Methionine--tRNA ligase

Reaction catalysed:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Systematic name:
L-methionine:tRNA(Met) ligase (AMP-forming)
Alternative Name(s):
  • MetRS
  • Methionine translase
  • Methionyl-tRNA synthetase
  • Methionyl-transfer RNA synthetase
  • Methionyl-transfer ribonucleate synthetase
  • Methionyl-transfer ribonucleic acid synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF09334
Domain description: tRNA synthetases class I (M)
Occurring in:
  1. Methionine--tRNA ligase
The deposited structure of PDB entry 5xet contains 2 copies of Pfam domain PF09334 (tRNA synthetases class I (M)) in Methionine--tRNA ligase. Showing 2 copies in chain A [auth C].

PF19303
Domain description: Anticodon binding domain of methionyl tRNA ligase
Occurring in:
  1. Methionine--tRNA ligase
The deposited structure of PDB entry 5xet contains 1 copy of Pfam domain PF19303 (Anticodon binding domain of methionyl tRNA ligase) in Methionine--tRNA ligase. Showing 1 copy in chain A [auth C].

InterPro InterPro annotations
IPR033911
Domain description: Methioninyl-tRNA synthetase core domain
Occurring in:
  1. Methionine--tRNA ligase
IPR041872
Domain description: Methionyl-tRNA synthetase, anticodon-binding domain
Occurring in:
  1. Methionine--tRNA ligase
IPR015413
Domain description: Methionyl/Leucyl tRNA synthetase
Occurring in:
  1. Methionine--tRNA ligase
IPR023457
Domain description: Methionine-tRNA synthetase, type 2
Occurring in:
  1. Methionine--tRNA ligase
IPR009080
Domain description: Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Occurring in:
  1. Methionine--tRNA ligase
IPR001412
Domain description: Aminoacyl-tRNA synthetase, class I, conserved site
Occurring in:
  1. Methionine--tRNA ligase
IPR014758
Domain description: Methionyl-tRNA synthetase
Occurring in:
  1. Methionine--tRNA ligase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Methionine--tRNA ligase

Structure domains

CATH CATH domains
3.40.50.620
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HUPs
Occurring in:
  1. Methionine--tRNA ligase
The deposited structure of PDB entry 5xet contains 1 copy of CATH domain 3.40.50.620 (Rossmann fold) in Methionine--tRNA ligase. Showing 1 copy in chain A [auth C].
1.10.730.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Isoleucyl-tRNA Synthetase; Domain 1
Homology: Isoleucyl-tRNA Synthetase; Domain 1
Occurring in:
  1. Methionine--tRNA ligase
The deposited structure of PDB entry 5xet contains 1 copy of CATH domain 1.10.730.10 (Isoleucyl-tRNA Synthetase; Domain 1) in Methionine--tRNA ligase. Showing 1 copy in chain A [auth C].
2.170.220.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Methionyl-trna Synthetase; domain 2
Homology: Methionyl-trna Synthetase; domain 2
Occurring in:
  1. Methionine--tRNA ligase
The deposited structure of PDB entry 5xet contains 1 copy of CATH domain 2.170.220.10 (Methionyl-trna Synthetase; domain 2) in Methionine--tRNA ligase. Showing 1 copy in chain A [auth C].

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