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Crystal structure of human DEAH-box RNA helicase DHX15 in complex with ADP

X-ray diffraction
2Å resolution
PDB entry 5xdr coloured by chain, front view.
PDB entry 5xdr coloured by chain, side view.
PDB entry 5xdr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-dependent RNA helicase DHX15
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Multimeric state: monomeric
Accessible surface area: 30715.13 Å2
Buried surface area: 1273.85 Å2
Dissociation area: 74.9 Å2
Dissociation energy (ΔGdiss): 12.54 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128835

Macromolecules

ATP-dependent RNA helicase DHX15
Chain: A
Length: 690 amino acids
Theoretical weight: 79.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43143 (Residues: 110-795; Coverage: 86%)
Gene names: DBP1, DDX15, DHX15
Pfam:
InterPro:
ATP-dependent RNA helicase DHX15 in PDB entry 5xdr, assembly 1, front view.
ATP-dependent RNA helicase DHX15 in PDB entry 5xdr, assembly 1, side view.
ATP-dependent RNA helicase DHX15 in PDB entry 5xdr, assembly 1, top view.
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