5xau

X-ray diffraction
1.8Å resolution

Crystal structure of integrin binding fragment of laminin-511

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Laminin subunit alpha-5 Chains: A, D
Molecule details ›
Chains: A, D
Length: 674 amino acids
Theoretical weight: 73.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15230 (Residues: 2655-3327; Coverage: 18%)
Gene names: KIAA0533, KIAA1907, LAMA5
Sequence domains: Laminin G domain
Laminin subunit beta-1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 74 amino acids
Theoretical weight: 8.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P07942 (Residues: 1714-1786; Coverage: 4%)
Gene name: LAMB1
Laminin subunit gamma-1 Chains: C, F
Molecule details ›
Chains: C, F
Length: 83 amino acids
Theoretical weight: 9.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P11047 (Residues: 1528-1609; Coverage: 5%)
Gene names: LAMB2, LAMC1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2
Unit cell:
a: 175.031Å b: 121.618Å c: 107.554Å
α: 90° β: 127.57° γ: 90°
R-values:
R R work R free
0.203 0.202 0.237
Expression system: Homo sapiens