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Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex

Source organisms:
Biochemical function: metal ion binding
Biological process: microtubule-based process
Cellular component: cytoplasm

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03953
Domain description: Tubulin C-terminal domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
The deposited structure of PDB entry 5xaf contains 2 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin alpha-1B chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5xaf contains 2 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin beta-2B chain. Showing 1 copy in chain B.

PF00091
Domain description: Tubulin/FtsZ family, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
The deposited structure of PDB entry 5xaf contains 2 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin alpha-1B chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5xaf contains 2 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin beta-2B chain. Showing 1 copy in chain B.

PF00836
Domain description: Stathmin family
Occurring in:
  1. Stathmin-4
The deposited structure of PDB entry 5xaf contains 1 copy of Pfam domain PF00836 (Stathmin family) in Stathmin-4. Showing 1 copy in chain E.

InterPro InterPro annotations
IPR000217
Domain description: Tubulin
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR002453
Domain description: Beta tubulin
Occurring in:
  1. Tubulin beta-2B chain
IPR002452
Domain description: Alpha tubulin
Occurring in:
  1. Tubulin alpha-1B chain
IPR000956
Domain description: Stathmin family
Occurring in:
  1. Stathmin-4
IPR018316
Domain description: Tubulin/FtsZ, 2-layer sandwich domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR003008
Domain description: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR036525
Domain description: Tubulin/FtsZ, GTPase domain superfamily
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR023123
Domain description: Tubulin, C-terminal
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR037103
Domain description: Tubulin/FtsZ-like, C-terminal domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR008280
Domain description: Tubulin/FtsZ, C-terminal
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR017975
Domain description: Tubulin, conserved site
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
IPR004344
Domain description: Tubulin-tyrosine ligase/Tubulin polyglutamylase
Occurring in:
  1. TTL Protein
IPR030514
Domain description: Stathmin, conserved site
Occurring in:
  1. Stathmin-4
IPR013838
Domain description: Beta tubulin, autoregulation binding site
Occurring in:
  1. Tubulin beta-2B chain
IPR036002
Domain description: Stathmin superfamily
Occurring in:
  1. Stathmin-4

Structure domains

CATH CATH domains
1.10.287.600
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix hairpin bin
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
The deposited structure of PDB entry 5xaf contains 2 copies of CATH domain 1.10.287.600 (Helix Hairpins) in Tubulin alpha-1B chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5xaf contains 2 copies of CATH domain 1.10.287.600 (Helix Hairpins) in Tubulin beta-2B chain. Showing 1 copy in chain B.
3.30.1330.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: 60s Ribosomal Protein L30; Chain: A;
Homology: Tubulin/FtsZ, C-terminal domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
The deposited structure of PDB entry 5xaf contains 2 copies of CATH domain 3.30.1330.20 (60s Ribosomal Protein L30; Chain: A;) in Tubulin alpha-1B chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5xaf contains 2 copies of CATH domain 3.30.1330.20 (60s Ribosomal Protein L30; Chain: A;) in Tubulin beta-2B chain. Showing 1 copy in chain B.
3.40.50.1440
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta-2B chain
The deposited structure of PDB entry 5xaf contains 2 copies of CATH domain 3.40.50.1440 (Rossmann fold) in Tubulin alpha-1B chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5xaf contains 2 copies of CATH domain 3.40.50.1440 (Rossmann fold) in Tubulin beta-2B chain. Showing 1 copy in chain B.
3.30.470.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: ATP-grasp fold, B domain
Occurring in:
  1. TTL Protein
The deposited structure of PDB entry 5xaf contains 1 copy of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in TTL ligase. Showing 1 copy in chain F.
3.30.1490.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: ATP-grasp fold, A domain
Occurring in:
  1. TTL Protein
The deposited structure of PDB entry 5xaf contains 1 copy of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in TTL ligase. Showing 1 copy in chain F.
3.40.50.11480
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. TTL Protein
The deposited structure of PDB entry 5xaf contains 1 copy of CATH domain 3.40.50.11480 (Rossmann fold) in TTL ligase. Showing 1 copy in chain F.
6.10.280.30
Class: Special
Architecture: Helix non-globular
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Occurring in:
  1. Stathmin-4
The deposited structure of PDB entry 5xaf contains 1 copy of CATH domain 6.10.280.30 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in Stathmin-4. Showing 1 copy in chain E.

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