X-ray diffraction
5.81Å resolution

Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain

Source organism: Mus musculus
Primary publication:
IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography.
Proc. Natl. Acad. Sci. U.S.A. 114 4661-4666 (2017)
PMID: 28416699

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Inositol 1,4,5-trisphosphate receptor type 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1581 amino acids
Theoretical weight: 181.01 KDa
Source organism: Mus musculus
Expression system: Spodoptera
  • Canonical: P11881 (Residues: 1-1581; Coverage: 58%)
Gene names: Insp3r, Itpr1, Pcd6, Pcp1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P42
Unit cell:
a: 128.164Å b: 128.164Å c: 369.486Å
α: 90° β: 90° γ: 90°
R R work R free
0.286 0.278 0.342
Expression system: Spodoptera