5x5o

X-ray diffraction
1.87Å resolution

Crystal structure of ZAK in complex with compound D2829

Released:
Source organism: Homo sapiens
Entry authors: Dai YB, Zhao P, Yun CH

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 20 Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NYL2 (Residues: 5-309; Coverage: 38%)
Gene names: HCCS4, MAP3K20, MLTK, ZAK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 131.057Å b: 48.501Å c: 42.625Å
α: 90° β: 105.48° γ: 90°
R-values:
R R work R free
0.192 0.19 0.226
Expression system: Spodoptera frugiperda