PDBe 5x4y

X-ray diffraction
2.2Å resolution

Mutant human thymidylate synthase M190K crystallized in a sulfate-containing condition

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate synthase Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 35.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04818 (Residues: 1-313; Coverage: 100%)
Gene names: OK/SW-cl.29, TS, TYMS
Sequence domains: Thymidylate synthase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P3121
Unit cell:
a: 95.951Å b: 95.951Å c: 80.89Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.235
Expression system: Escherichia coli