PDBe 5x24

X-ray diffraction
2.48Å resolution

Crystal structure of CYP2C9 genetic variant I359L (*3) in complex with multiple losartan molecules

Released:
Source organism: Homo sapiens

Function and Biology Details

Reactions catalysed:
(+)-(R)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (+)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)-perillyl alcohol + [oxidized NADPH--hemoprotein reductase] + H(2)O
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2C9 Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 54.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11712 (Residues: 19-490; Coverage: 96%)
Gene names: CYP2C10, CYP2C9
Sequence domains: Cytochrome P450

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: I222
Unit cell:
a: 74.858Å b: 141.777Å c: 160.656Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.229 0.27
Expression system: Escherichia coli