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Crystal structure of CYP2C9 genetic variant A477T (*30) in complex with multiple losartan molecules

X-ray diffraction
2Å resolution
PDB entry 5x23 coloured by chain, front view.
PDB entry 5x23 coloured by chain, side view.
PDB entry 5x23 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytochrome P450 2C9
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Multimeric state: monomeric
Accessible surface area: 19593.85 Å2
Buried surface area: 1586.54 Å2
Dissociation area: 94.35 Å2
Dissociation energy (ΔGdiss): 0.16 kcal/mol
Dissociation entropy (TΔSdiss): 0.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145899

Macromolecules

Cytochrome P450 2C9
Chain: A
Length: 476 amino acids
Theoretical weight: 54.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11712 (Residues: 19-490; Coverage: 96%)
Gene names: CYP2C10, CYP2C9
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
Cytochrome P450 2C9 in PDB entry 5x23, assembly 1, front view.
Cytochrome P450 2C9 in PDB entry 5x23, assembly 1, side view.
Cytochrome P450 2C9 in PDB entry 5x23, assembly 1, top view.
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