X-ray diffraction
2.3Å resolution

Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
GlgA glycogen synthase; Orexin receptor type 2 Chain: A
Molecule details ›
Chain: A
Length: 560 amino acids
Theoretical weight: 64.2 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
  • Canonical: O43614 (Residues: 3-254, 294-388; Coverage: 78%)
Gene names: HCRTR2, PAB2292
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SACLA BEAMLINE BL3
Spacegroup: C2
Unit cell:
a: 97.51Å b: 75.98Å c: 96.1Å
α: 90° β: 112.3° γ: 90°
R R work R free
0.2 0.199 0.219
Expression system: Spodoptera frugiperda