› 5wqg

X-ray diffraction
2.3Å resolution

Structure of fungal meroterpenoid isomerase Trt14 complexed with terretonin D

Released:
DOI: 10.2210/pdb5wqg/pdb
PDB entry 5wqg coloured by chain, front view.
PDB entry 5wqg coloured by chain, side view.
PDB entry 5wqg coloured by chain, top view.
Source organism: Aspergillus terreus NIH2624
Primary publication:
Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis.
Mori T, Iwabuchi T, Hoshino S, Wang H, Matsuda Y, Abe I
Nat Chem Biol 13 1066-1073 (2017)
PMID: 28759016

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170871 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isomerase trt14 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 162 amino acids
Theoretical weight: 18.32 KDa
Source organism: Aspergillus terreus NIH2624
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0C8A2 (Residues: 1-142; Coverage: 100%)
Gene names: ATEG_10082, trt14

Ligands and Environments

2 bound ligands:
Ligand CA 6 x CA
Ligand 7MI 3 x 7MI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: P21
Unit cell:
a: 99.44Å b: 47.13Å c: 121.13Å
α: 90° β: 107.97° γ: 90°
R-values:
R R work R free
0.198 0.196 0.245
Expression system: Escherichia coli

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Citations

4 review citations

Marine natural products.
Carroll et al. (2019)
3 more