X-ray diffraction
2.3Å resolution

Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to HMG-CoA and in a partially closed conformation

Source organism: Streptococcus pneumoniae
Entry authors: Miller BR, Kung Y

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
3-hydroxy-3-methylglutaryl coenzyme A reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 426 amino acids
Theoretical weight: 46.46 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8DNS5 (Residues: 1-424; Coverage: 100%)
Gene names: mvaA, spr1570
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:

Ligands and Environments

Cofactor: Ligand HMG 2 x HMG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 57.865Å b: 131.248Å c: 57.957Å
α: 90° β: 102.54° γ: 90°
R R work R free
0.187 0.177 0.233
Expression system: Escherichia coli BL21(DE3)