› 5woe

Solution NMR

Solution structure of the sorting nexin 25 phox-homology domain

Released:
DOI: 10.2210/pdb5woe/pdb
PDB entry 5woe coloured by chain, ensemble of 20 models, front view.
PDB entry 5woe coloured by chain, ensemble of 20 models, side view.
PDB entry 5woe coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Chandra M, Chin YK, Mas C, Feathers JR, Paul B, Datta S, Chen KE, Jia X, Yang Z, Norwood SJ, Mohanty B, Bugarcic A, Teasdale RD, Henne WM, Mobli M, Collins BM
Nat Commun 10 1528 (2019)
PMID: 30948714

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190573 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-25 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H3E2 (Residues: 506-628; Coverage: 15%)
Gene names: MSTP043, SNX25
Sequence domains: PX domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Novel roles of phosphoinositides in signaling, lipid transport, and disease.
Hammond et al. (2020)
25 more

5 mentions without citation

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Chandra et al. (2019)
4 more