› 5wky

X-ray diffraction
4Å resolution

Bromide sites in the structure of an acid sensing ion channel in a resting state

Released:
DOI: 10.2210/pdb5wky/pdb
PDB 5wky coloured by chain and viewed from the front.
PDB 5wky coloured by chain and viewed from the side.
PDB 5wky coloured by chain and viewed from the top.
Source organism: Gallus gallus
Entry authors: Yoder N, Gouaux E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 439 amino acids
Theoretical weight: 50.24 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1XA76 (Residues: 25-463; Coverage: 83%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand CL 3 x CL
Ligand BA 1 x BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 109.55Å b: 134.49Å c: 159.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.282 0.281 0.299
Expression system: Homo sapiens

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Citations

1 review citation

Nociceptor Signalling through ion Channel Regulation via GPCRs.
Salzer et al. (2019)
11 other articles