› 5wkv

X-ray diffraction
3.2Å resolution

Structure of an acid sensing ion channel in a resting state with calcium

Released:
DOI: 10.2210/pdb5wkv/pdb
PDB 5wkv coloured by chain and viewed from the front.
PDB 5wkv coloured by chain and viewed from the side.
PDB 5wkv coloured by chain and viewed from the top.
Source organism: Gallus gallus
Entry authors: Yoder N, Gouaux E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 439 amino acids
Theoretical weight: 50.24 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1XA76 (Residues: 25-463; Coverage: 83%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand CL 2 x CL
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 109.18Å b: 133.7Å c: 157.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.287 0.297
Expression system: Homo sapiens

Quick links

Citations

14 review citations

Acid-Sensing Ion Channels in Glial Cells.
Cegielski et al. (2022)
13 more

1 mention without citation

Thumb domains of the three epithelial Na+ channel subunits have distinct functions.
Sheng et al. (2018)