5wkv

X-ray diffraction
3.2Å resolution

Structure of an acid sensing ion channel in a resting state with calcium

Released:
Source organism: Gallus gallus
Entry authors: Yoder N, Gouaux E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 439 amino acids
Theoretical weight: 50.24 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1XA76 (Residues: 25-463; Coverage: 83%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 109.18Å b: 133.7Å c: 157.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.287 0.297
Expression system: Homo sapiens