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D30 TCR in complex with HLA-A*11:01-GTS3

Source organisms:
Biochemical function: protein homodimerization activity
Biological process: response to bacterium
Cellular component: plasma membrane

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EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.21.91: Flavivirin

Reaction catalysed:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Alternative Name(s):
  • NS2B-3 proteinase
  • Yellow fever virus (flavivirus) protease
  • Yellow fever virus protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

EC 2.1.1.57: Methyltransferase cap1

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Alternative Name(s):
  • Cap1-MTase
  • MTR1
  • Messenger RNA (nucleoside-2'-)-methyltransferase
  • Messenger ribonucleate nucleoside 2'-methyltransferase
  • S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
  • mRNA (nucleoside-2'-O)-methyltransferase

EC 2.1.1.56: mRNA (guanine-N(7))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:mRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
  • Guanine-7-methyltransferase
  • Messenger RNA guanine 7-methyltransferase
  • Messenger ribonucleate guanine 7-methyltransferase
  • S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
The deposited structure of PDB entry 5wkh contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 5wkh contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 1 copy in chain G.

PF09291
Domain description: Domain of unknown function (DUF1968)
Occurring in:
  1. Ig-like domain-containing protein; T cell receptor alpha variable 30
The deposited structure of PDB entry 5wkh contains 2 copies of Pfam domain PF09291 (Domain of unknown function (DUF1968)) in Ig-like domain-containing protein. Showing 1 copy in chain D.

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig-like domain-containing protein; T cell receptor alpha variable 30
The deposited structure of PDB entry 5wkh contains 2 copies of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain D.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 5wkh contains 2 copies of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. D30 TCR beta chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. Ig-like domain-containing protein; T cell receptor alpha variable 30
  4. D30 TCR beta chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. Ig-like domain-containing protein; T cell receptor alpha variable 30
  4. D30 TCR beta chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. Ig-like domain-containing protein; T cell receptor alpha variable 30
  4. D30 TCR beta chain
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR015370
Domain description: T-cell receptor alpha chain, constant domain
Occurring in:
  1. Ig-like domain-containing protein; T cell receptor alpha variable 30
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Ig-like domain-containing protein; T cell receptor alpha variable 30
  2. D30 TCR beta chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig-like domain-containing protein; T cell receptor alpha variable 30
  2. D30 TCR beta chain
IPR015707
Domain description: Beta-2-Microglobulin
Occurring in:
  1. Beta-2-microglobulin
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. Ig-like domain-containing protein; T cell receptor alpha variable 30
  4. D30 TCR beta chain
The deposited structure of PDB entry 5wkh contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 5wkh contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 1 copy in chain G.
The deposited structure of PDB entry 5wkh contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 1 copy in chain D.
The deposited structure of PDB entry 5wkh contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in D30 TCR beta chain. Showing 2 copies in chain E.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 5wkh contains 2 copies of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

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