PDBe 5weo

Electron Microscopy
4.2Å resolution

Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2; Voltage-dependent calcium channel gamma-2 subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1034 amino acids
Theoretical weight: 115.5 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: O88602 (Residues: 2-205, 206-208; Coverage: 64%)
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • nullnull
Gene names: Cacng2, Glur2, Gria2, Stg
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-8823
Expression system: Homo sapiens