5wcs

X-ray diffraction
2.52Å resolution

Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6b (SRI-29789)

Released:
Entry authors: Kumar G, White SW

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase acidic protein Chain: A
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 21.97 KDa
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: C3W5S0 (Residues: 1-50, 73-196; Coverage: 24%)
Gene name: PA
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Structure domains: Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6422
Unit cell:
a: 74.666Å b: 74.666Å c: 125.722Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.24
Expression system: Escherichia coli BL21(DE3)