5wbg

X-ray diffraction
2.99Å resolution

Crystal Structure of human Cytochrome P450 2B6 (Y226H/K262R) in complex with an analog of a drug Efavirenz

Released:
Source organism: Homo sapiens
Primary publication:
Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog.
OpenAccess logo Int J Mol Sci 19 (2018)
PMID: 29596329

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2B6 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 476 amino acids
Theoretical weight: 54.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20813 (Residues: 20-491; Coverage: 96%)
Gene name: CYP2B6
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P21
Unit cell:
a: 103.293Å b: 197.786Å c: 119.222Å
α: 90° β: 98.51° γ: 90°
R-values:
R R work R free
0.229 0.227 0.262
Expression system: Escherichia coli