Structure analysis

COX-1:MOFEZOLAC COMPLEX STRUCTURE

X-ray diffraction
2.75Å resolution
Source organism: Ovis aries
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 43000 Å2
Buried surface area: 15700 Å2
Dissociation area: 3,000 Å2
Dissociation energy (ΔGdiss): 15 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): 11 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B
Length: 600 amino acids
Theoretical weight: 68.94 KDa
Source organism: Ovis aries
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P05979 (Residues: 1-600; Coverage: 100%)
Gene names: COX1, PTGS1
Pfam:
InterPro:
CATH:

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