5wbe

X-ray diffraction
2.75Å resolution

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Prostaglandin G/H synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 600 amino acids
Theoretical weight: 68.94 KDa
Source organism: Ovis aries
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P05979 (Residues: 1-600; Coverage: 100%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand HEM 2 x HEM
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P65
Unit cell:
a: 180.925Å b: 180.925Å c: 104.248Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.195 0.228
Expression system: unidentified baculovirus