5w7y

X-ray diffraction
2.1Å resolution

Crystal Structure of FHA domain of human APLF in complex with XRCC1 monophosphorylated mutated peptide

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-148466 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aprataxin and PNK-like factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 11.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IW19 (Residues: 1-105; Coverage: 21%)
Gene names: APLF, C2orf13, PALF, XIP1
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4
DNA repair protein XRCC1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 8 amino acids
Theoretical weight: 961 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P18887 (Residues: 514-521; Coverage: 1%)
Gene name: XRCC1

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 54.799Å b: 31.072Å c: 118.908Å
α: 90° β: 97.84° γ: 90°
R-values:
R R work R free
0.204 0.203 0.237
Expression systems:
  • Escherichia coli
  • Not provided