X-ray diffraction
2.1Å resolution

X-ray structure of ankyrin repeat domain of DHHC17 in complex with Snap25b peptide


Function and Biology Details

Reaction catalysed:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Palmitoyltransferase ZDHHC17 Chains: A, C
Molecule details ›
Chains: A, C
Length: 239 amino acids
Theoretical weight: 26.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8IUH5 (Residues: 50-284; Coverage: 37%)
Gene names: HIP14, HIP3, HSPC294, HYPH, KIAA0946, ZDHHC17
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain
Synaptosomal-associated protein 25 Chains: B, D
Molecule details ›
Chains: B, D
Length: 10 amino acids
Theoretical weight: 984 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P60880 (Residues: 111-120; Coverage: 5%)
Gene names: SNAP, SNAP25

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P64
Unit cell:
a: 88.187Å b: 88.187Å c: 127.969Å
α: 90° β: 90° γ: 120°
R R work R free
0.178 0.176 0.222
Expression systems:
  • Escherichia coli
  • Not provided