5w55

X-ray diffraction
1.35Å resolution

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048

Released:
Source organism: Homo sapiens
Entry authors: Xu X, Blacklow SC

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 42-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 43.411Å b: 51.351Å c: 56.755Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.195
Expression system: Escherichia coli