› 5w55

X-ray diffraction
1.35Å resolution

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048

Released:
DOI: 10.2210/pdb5w55/pdb
PDB 5w55 coloured by chain and viewed from the front.
PDB 5w55 coloured by chain and viewed from the side.
PDB 5w55 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Xu X, Blacklow SC

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 42-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand X30 1 x X30
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 43.411Å b: 51.351Å c: 56.755Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.195
Expression system: Escherichia coli

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