Function and Biology

Yeast microtubule stabilized with Taxol assembled from mutated tubulin

Source organism: Saccharomyces cerevisiae S288C
Biochemical function: GTPase activity
Biological process: microtubule-based process
Cellular component: kinetochore microtubule

Sequence families

Pfam Protein families (Pfam)
PF00091
Domain description: Tubulin/FtsZ family, GTPase domain
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
1 copy of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin alpha-1 chain in PDB 5w3j.
2 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin beta chain in PDB 5w3j.

PF03953
Domain description: Tubulin C-terminal domain
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
1 copy of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin alpha-1 chain in PDB 5w3j.
2 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin beta chain in PDB 5w3j.

InterPro InterPro annotations
IPR000217
Domain description: Tubulin
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
IPR002452
Domain description: Alpha tubulin
Occurring in:
  1. Tubulin alpha-1 chain
IPR002453
Domain description: Beta tubulin
Occurring in:
  1. Tubulin beta chain
IPR003008
Domain description: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
IPR036525
Domain description: Tubulin/FtsZ, GTPase domain superfamily
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
IPR018316
Domain description: Tubulin/FtsZ, 2-layer sandwich domain
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
IPR037103
Domain description: Tubulin/FtsZ, C-terminal domain superfamily
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
IPR023123
Domain description: Tubulin, C-terminal
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
IPR008280
Domain description: Tubulin/FtsZ, C-terminal
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain

Structure domains

CATH CATH domains
3.40.50.1440
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
1 copy of CATH domain 3.40.50.1440 (Rossmann fold) in Tubulin alpha-1 chain in PDB 5w3j.
2 copies of CATH domain 3.40.50.1440 (Rossmann fold) in Tubulin beta chain in PDB 5w3j.
3.30.1330.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: 60s Ribosomal Protein L30; Chain: A;
Homology: Tubulin/FtsZ, C-terminal domain
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
1 copy of CATH domain 3.30.1330.20 (60s Ribosomal Protein L30; Chain: A;) in Tubulin alpha-1 chain in PDB 5w3j.
2 copies of CATH domain 3.30.1330.20 (60s Ribosomal Protein L30; Chain: A;) in Tubulin beta chain in PDB 5w3j.
1.10.287.600
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix hairpin bin
Occurring in:
  1. Tubulin alpha-1 chain
  2. Tubulin beta chain
1 copy of CATH domain 1.10.287.600 (Helix Hairpins) in Tubulin alpha-1 chain in PDB 5w3j.
2 copies of CATH domain 1.10.287.600 (Helix Hairpins) in Tubulin beta chain in PDB 5w3j.