› 5w2o

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
An ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO(2) + a holo-[acyl-carrier protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162071 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-[acyl-carrier-protein] synthase 1 Chain: A
Molecule details ›
Chain: A
Length: 439 amino acids
Theoretical weight: 45.79 KDa
Source organism: Mycobacterium tuberculosis str. Erdman = ATCC 35801
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: P9WQD9 (Residues: 1-416; Coverage: 100%)
Gene names: MTCY427.26, Rv2245, kasA
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

5 bound ligands:
Ligand NA 1 x NA
Ligand GOL 4 x GOL
Ligand IPA 3 x IPA
Ligand TCE 1 x TCE
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P3121
Unit cell:
a: 77.389Å b: 77.389Å c: 147.008Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.155 0.154 0.179
Expression system: Mycolicibacterium smegmatis MC2 155

Quick links

Citations

11 review citations

Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets.
Oh et al. (2021)
10 more

3 mentions without citation

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.
Kumar et al. (2018)
2 more