5w06

X-ray diffraction
2.6Å resolution

HUMAN TISSUE FACTOR IN COMPLEX WITH ANTIBODY M1587

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-230857 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tissue factor Chain: T
Molecule details ›
Chain: T
Length: 215 amino acids
Theoretical weight: 24.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13726 (Residues: 37-245; Coverage: 80%)
Gene name: F3
Sequence domains:
Structure domains: Immunoglobulins
M1587 FAB LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.19 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
M1587 FAB HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.55 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21212
Unit cell:
a: 68.1Å b: 175.56Å c: 63.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.235
Expression system: Homo sapiens