5vz4

X-ray diffraction
2.2Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth/differentiation factor 15 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99988 (Residues: 197-308; Coverage: 40%)
Gene names: GDF15, MIC1, PDF, PLAB, PTGFB
Sequence domains: Transforming growth factor beta like domain
GDNF family receptor alpha-like Chain: B
Molecule details ›
Chain: B
Length: 245 amino acids
Theoretical weight: 27.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6UXV0 (Residues: 115-351; Coverage: 63%)
Gene names: C6orf144, GFRAL, UNQ9356/PRO34128
Sequence domains: GDNF/GAS1 domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: I222
Unit cell:
a: 75.352Å b: 88.768Å c: 121.293Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.191 0.254
Expression systems:
  • Homo sapiens
  • Spodoptera frugiperda